Kenneth Allen, Food Science & Human Nutrition -- Research directed at determining: 1) the effects of dietary copper on hepatic glutathione redox state, cholesterol synthesis, and hepatic gene expression; and 2) the role of n-3/n-6 polyunsaturated fatty acids in health maintenance.
Russell V. Anthony, Biomedical Sciences -- My laboratory addresses the broad objective of understanding the regulation of placental and fetal metabolism. We are particularly interested in identifying the transitional regulation of placental hormones, and characterizing how placental-fetal interactions contribute to fetal glucose metabolism.
Nancy DuTeau, Microbiology, Immunology, and Pathology -- Research directed at developing markers for population studies, genetic fingerprinting, and species identification. These genetic markers are used for studies of molecular epidemiology of infectious disease organisms, bioremediation by environmental microbes, and environmental exposure of animals to hazardous substances.
Scott Earley, Biomedical Sciences -- My research is focused on investigating roles of ion channels from the transient receptor potential (TRP) superfamily in the regulation of cerebral artery function. I am also interested in mechanisms of neurovascular coupling during normal and pathophysiological conditions.
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| Dr. Florant |
Robert Gotshall, Health & Exercise Science -- Research directed at determining: 1) the effect of menopause on blood lipid responses to a meal; and 2) the effect of homocysteine (raised by ingesting methionine) on endothelial cell function in humans using non-invasive imaging techniques.
Matt Hickey, Health & Exercise Science -- Research directed at determining: 1) how diet regulates UCP gene expression in skeletal muscle; and 2) the effects of an oral insulin-like growth factor (IGF-1) secretagogue on skeletal muscle and endocrine adaptations to resistance exercise.
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| Dr. Ishii |
Shane Kanatous, Biology -- My research combines my expertise in exercise and skeletal muscle physiology with molecular techniques to focus on oxygen metabolism; especially on the control and regulation of skeletal and cardiac muscle adaptations to extreme environmental conditions such as hypoxia. The ultimate goal is to enhance our understanding of molecular changes associated with hypoxia and translate these results for therapeutic applications in the treatment of myopathies.
Chris Melby, Food Science & Human Nutrition -- Research directed at determining nutritional, exercise, and social factors that influence the development of hypertension, particularly in minority populations.
Don Mykles, Biology -- Research directed at determining the role of a limb autonomy factor, LAFpro, that is synthesized by regenerating tissues, in cardiovascular response to injury or ischemia.
Tracy L. Nelson, Health & Exercise Science -- My research addresses gene/environment interactions in the development of obesity and Type 2 diabetes. We combine epidemiologic studies of candidate gene polymorphisms with clinical studies in which we manipulate dietary fat intake.
Chris Orton, Clinical Sciences -- Research directed at developing a hybrid xenograft/autograft heart valve in which the native cells from the xenograft heart valve are removed (i.e., de-cellularized) and replaced with autogenous cells from the recipient patient prior to implantation (i.e., re-cellularized).
Michael J. Pagliassotti, Food Science & Human Nutrition -- My laboratory is primarily interested in nutrient regulation of hepatic glucose metabolism. Within this broad framework, we are currently investigating simple sugar regulation of glucose-6-phosphatase gene transcription, the mechanisms involved in sucrose-induced hepatic insulin resistance, the acute and chronic effects of intrahepatic lipids on insulin signaling, and the role of the endoplasmic reticulum as a nutrient sensing organelle. We use a combination of in vivo and in vitro models that combine complex tracer methods with basic and advanced cellular and molecular biology techniques.
Barbara Sanborn, Biomedical Sciences -- Hormones are molecular signals that alter cell function. Understanding how hormones convey their signals is critical for understanding basic cell biology and disease states, and for designing intervention strategies. Research in the Sanborn laboratory focuses on defining the molecular signal transduction pathways of hormone action relating to the control of development and differentiation in several systems. Signaling crosstalk: The control of uterine contraction/relaxation is critical to the maintenance of pregnancy and the efficient delivery of the neonate. Uterine contractants such as oxytocin increase intracellular calcium in uterine muscle cells by increasing influx and release from intracellular stores secondary to phospholipase C (PLC) activation. Relaxants oppose these actions by regulatory phosphorylation mechanisms. The Sanborn laboratory is determining the biochemical basis for the regulatory role of phosphorylation and changes in key signaling pathways that occur during pregnancy. These changes involve alteration in the expression and intracellular localization of proteins. Membrane receptors: The Sanborn laboratory is investigating the structural basis for the coupling between specific receptors, intermediate G-proteins and PLCs using recombinant DNA techniques. Calcium dynamics: The Sanborn laboratory is studying hormonal effects on intracellular calcium dynamics by single cell immunofluorescence and effects of hormones on ion channel activity and expression.
Mike Tamkun, Biomedical Sciences -- Research directed at determining: 1) the localization and subunit composition of voltage-gated potassium channels in cardiovascular tissue; 2) the expression and function of Nav2 sodium channel family members in cardiac and uterine smooth muscle; and 3) the expression, distribution, and subunit composition of oxygen-sensitive potassium channels in pulmonary arteries from normal and pulmonary hypertensive calves.