Biology Directory: Cell + Molecular Biology

Salah Abdel-Ghany

Special Assistant Professor
Ph.D., Colorado State University

My research focuses on understanding the regulation of gene expression in response to abiotic stresses at the transcriptional and post-transcriptional levels including chromatin modifications, pre-mRNA splicing and small noncoding RNAs.

Patricia Bedinger 

Professor
Ph.D., University of California, San Francisco

The work in my laboratory centers on reproductive barriers between higher plant species, in particular between species wild tomatoes. We are examining the molecular and cellular nature of interspecific reproductive barriers (IRB).

Daniel R Bush

Professor and Vice Provost for Faculty Affairs
Ph.D., UC Berkeley

My research focuses on sugar and amino acid allocation from sites of primary assimilation to import-dependent sinks in plants. This is a fundamental process that allows plants to function as multicellular organisms. We use molecular, genetic and biochemical tools to define the mechanisms and regulation of this essential process.

Deborah Garrity

Professor and Director, Life Science Core; CNS Professor Laureate
Ph.D., Cornell University

The embryonic heart begins pumping blood even before the cardiac organ is fully formed. Our group is interested in the genetic and biomechanical factors that contribute to normal heart development. We use the zebrafish model to study how the initial heart tube transitions into a rhythmic, efficient multi-chambered organ. Our approaches include quantitative live imaging, developmental genetic techniques, and modern genomic tools.

Kim Hoke

Associate Professor

The primary goal of the Hoke lab is to understand the processes that shape evolutionary trajectories. We focus on the mechanisms of convergent evolution of behavioral and morphological traits. We link molecular, neural, and developmental mechanisms to their consequences for organismal phenotypes, and we investigate the neural and hormonal mechanisms of context- or experience-dependent changes in behavior.

Shane Kanatous

Associate Professor
PhD

My research combines my expertise in exercise and skeletal muscle physiology with molecular techniques to focus on oxygen metabolism; especially on the control and regulation of skeletal and cardiac muscle adaptations to extreme environmental conditions such as hypoxia. The ultimate goal is to enhance our understanding of molecular changes associated with hypoxia and translate these results for therapeutic applications in the treatment of myopathies.

June Medford

Professor
Ph.D., Yale University

We work on Plant Synthetic Biology. Synthetic Biology is forward engineering of biological organisms for specific purposes both basic and applied. On the basic side, we are using synthetic biology to understand complex natural processes such as signal transduction and pattern formation. We are using synthetic biology to produce new types of plants and plant traits such as highly specific plant detectors, plants producing biofuels and plant that do useful things for humans and the environment

Tai Montgomery

Assistant Professor

Our lab studies small non-coding RNAs and their roles in gene regulation and genome defense.

Kevin Morey

Special Assistant Professor
Ph.D., New Mexico State University

My research interest is two component signal transduction. My current work includes both basic and applied research on two-component signal transduction for use in plant biodetectors.

Rachel Mueller

Associate Professor
Ph.D., University of California, Berkeley

I am interested in three basic questions in evolutionary biology: (1) How do genomes evolve, particularly those at the extremes of genome size? (2) How do transposable elements shape genome biology and evolution? (3) How does genome size impact phenotype and the evolutionary trajectories of lineages?

Don Mykles

Professor; Director University Honors Program
Ph.D., University of California, Berkeley

I study the regulation of molting and limb regeneration in decapod crustaceans using molecular biological, transcriptomic, and proteomic methods. I am also Director of the University Honors Program (http://www.honors.colostate.edu).

Marc Nishimura

Assistant Professor
Ph.D., Stanford University

My research group studies the molecular mechanisms determining the outcome of plant-microbe interactions. We’re particularly interested in how plant immune receptors function to limit pathogens and how pathogens seek to subvert host defenses. The plant immune system and pathogen virulence mechanisms are in an endless battle over evolutionary timescales. Understanding this arms race at a mechanistic level will reveal critical strategies for engineered disease resistance and improvement of our agricultural systems.

Graham Peers

Associate Professor

My primary interests lie in the fields of photosynthesis and algal eco-physiology. In particular, I’m interested in the diversity of mechanisms that algae use to protect themselves from too much light and other abiotic stresses.

Marinus Pilon

Professor
Ph.D., Utrecht University, The Netherlands

My lab investigates how the photosynthetic machinery in plants acquires the essential metal cofactors copper and iron. These metal ions are required for photosynthesis and thus plant productivity, yet they are toxic at too high concentrations. We use genetics together with whole plant physiology, cell and molecular biology and biochemistry in the model plant Arabidopsis to unravel the regulation of copper delivery and the assembly of iron-sulfur clusters in proteins.

Elizabeth Pilon-Smits

Professor
Ph.D., Utrecht University, The Netherlands

In the Pilon-Smits lab we are interested in processes by which plants accumulate and detoxify environmental pollutants, as well as in ecological and evolutionary aspects of selenium hyperaccumulation. We study these processes from the molecular level to the field. Our approaches include genomics, genetics, biotechnology, biochemistry, whole-plant physiology, and ecological studies. These studies are aimed to gain knowledge about basic biological processes, but have applications for the use of plants for environmental cleanup or as fortified foods.

A.S.N. Reddy

Professor
Ph.D., Jawaharlal Nehru University

One of the fundamental questions in plant biology is how plants sense and respond to environmental (abiotic and biotic) and hormonal signals that regulate diverse cellular processes and various aspects of plant growth and development. Our group has been studying i) calcium-mediated signal transduction mechanisms with emphasis on calcium sensors and their target proteins, ii) mechanisms that regulate basic and alternative splicing of pre-messenger RNAs in response to stresses, iii) disease resistance, iv) cell wall degrading enzymes for biofuel production and iv) synthetic signal transduction circuits in plants. We use molecular, cell biological, genetic, biochemical, bioinformatics and computational tools to accomplish our research goals. Arabidopsis, maize, potato and Miscanthus are used in our research. Studies on computational aspects of alternative splicing and protein-protein interactions are being done in collaboration with Asa Ben-Hur in the Department of Computer Science at CSU (http://www.cs.colostate.edu/~asa/projects.html).

Dan Sloan

Assistant Professor
Ph.D. University of Virginia

My research investigates the evolutionary forces that create diversity in genome size, structure, and function. I am particularly interested in the evolution of so-called “resident genomes” that exist inside the cells of another organism, including those of mitochondria and plastids in eukaryotes and endosymbiotic bacteria in many insects. Much of my current work focuses on how these resident genomes co-evolve with the host genome.

Stephen Stack

Emeritus Professor
Ph.D., University of Texas, Austin

Recombination nodules (RNs) are ellipsoidal particles lying on the central element of the synaptonemal complex (SC) during zygotene and pachytene of meiosis in eukaryotic organisms. RNs seem to reside at the sites of reciprocal recombination events in late pachytene nuclei. We are studying the temporal development, spatial distribution, and biochemistry of RNs and SCs.