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SUMMARY:New Cellular and Interkingdom Functions Afforded by the Biosynthesi
 s of Non-standard Amino Acids
LOCATION:Biology 134
TZID:America/Denver
DTSTART:20240930T160000
UID:2026-05-24-00-31-19@natsci.colostate.edu
DTSTAMP:20260524T003119
Description:Speaker Bio\nAditya Kunjapur is an Assistant Professor and the 
 Thomas Willing Early Career Professor of Chemical &amp\; Biomolecular Engi
 neering at the University of Delaware. He earned B.S. and Ph.D. degrees in
  Chemical Engineering from the University of Texas at Austin and MIT in 20
 10 and 2015\, respectively. After conducting post-doctoral research with G
 eorge Church at Harvard Medical School\, Aditya started his lab at Delawar
 e in Dec. 2018. His lab seeks to expand the microbial chemistry repertoire
  to include new-to-nature building blocks for applications in human and pl
 anetary health. The lab\\'s work has been recognized through awards such a
 s the Langer Prize from AIChE\, a New Innovation Award from FFAR\, an NIH 
 Director\\'s New Innovator Award\, an ONR YIP\, the SIMB Early Career Awar
 d\, and the BioInnovation Institute &amp\; Science Grand Prize for Innovat
 ion. When not at work\, Aditya enjoys entertaining his two young girls.\nA
 bstract\nWhether in our guts or in the environment\, microbes play critica
 l roles in shaping the health of natural systems. Thanks to advances in sy
 nthetic biology\, we can reliably engineer microbes to augment their natur
 al capabilities or to impart them with new-to-nature functions. Our potent
 ial use of engineered microbes in open systems rather than in bioreactors 
 could help address diverse challenges in human and environmental health. H
 owever\, we face a few barriers before we can deploy engineered microbes e
 ffectively and safely. First\, we cannot yet engineer microbial factories 
 to produce many of the kinds of functional group chemistries that are char
 acteristic of the most effective synthetic medicines\, agrochemicals\, or 
 materials. Second\, we cannot yet reliably control the proliferation of an
  engineered microbe to mitigate the risk of unintended spread. Our lab has
  been making exciting progress tackling both of these topics\, all with a 
 common big picture strategy of programming cells to create and harness rar
 e building blocks. In this talk\, I will present three vignettes of where 
 the biosynthesis of non-standard amino acids (nsAAs) can enable new opport
 unities. Specifically\, I will describe new capabilities that have relevan
 ce to medicine and sensing. I will devote more time to the discussion of s
 afeguards that offer the promise to control the survival and functions of 
 engineered microbes in the environment for purposes such as agriculture or
  bioremediation. 4:00 pm
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