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SUMMARY:PhD Seminar: Temperature Sensitivity as a Microbial Trait
LOCATION:Yates 206
TZID:America/Denver
DTSTART:20174201T000000
UID:2026-04-21-08-07-38@natsci.colostate.edu
DTSTAMP:20260421T080738
Description:Reaction rates in biological systems are strongly controlled by
  temperature\, yet the degree to which temperature sensitivity varies for 
 different enzymes and microorganisms is being largely reformulated. The Ar
 rhenius equation is the most commonly used model over the last century tha
 t predicts reaction rate response with temperature. However\, the Arrheniu
 s equation does not account for large heat capacities associated with enzy
 mes in biological reactions\, thus creating significant deviations from pr
 edicted reaction rates. A relatively new model\, Macromolecular Rate Theor
 y (MMRT)\, modifies the Arrhenius equation by accounting for the temperatu
 re dependence of these large heat capacities found in biological reactions
 . Using the MMRT model I have developed a novel framework to assess temper
 ature sensitivity as a biological trait through a series of experiments pr
 oviding evidence that microbes and enzymes can have distinct heat capaciti
 es\, and thus distinct temperature sensitivities\, independent of their ex
 ternal environment. I first assessed temperature sensitivity of soil CO2 p
 roduction from different soil microbial communities. I then worked with pu
 re cultures to examine temperature sensitivity of enzyme activities from s
 oil microbial isolates and determined that temperature sensitivity varies 
 based on genetic variation of the microbe and substrate type. Finally\, I 
 used a meta-analysis to analyze the distribution of temperature sensitivit
 y traits to look across a variety of biological systems (e.g.\, the food i
 ndustry\, wastewater treatment\, soils) in order to identify commonalities
  in temperature responses across these diverse organisms and biological re
 action rates. 4:00 pm
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