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SUMMARY:Uncultivated but not uncharacterized microbes in the global oceans
LOCATION:Anatomy/Zoology Building W118
TZID:America/Denver
DTSTART:20123001T000000
UID:2026-05-24-02-25-39@natsci.colostate.edu
DTSTAMP:20260524T022539
Description:The Global Ocean Sampling project was initiated in the fall of 
 2003.  Since then\, samples have been collected from over 500 locations i
 n most of Earth’s major oceans and seas.  In parallel\, the number of c
 ompleted microbial genomes numbers in the 1000’s\, thus it was sobering 
 to find that only approximately a quarter of the GOS dataset could be asso
 ciated with a reference genome.   Essentially\, many of the most abundan
 t and theoretically important microbes are not cultivated.  To address th
 is shortfall\, genomes were assembled directly from the metagenomic datase
 ts\, while abundant and uncultivated OTUs were targeted for single cell ge
 nomics.    In one study\, complete genomes of previously unrecognized c
 lades of the cyanobacterium Prochlorococcus were assembled from stations i
 n the south Pacific.  Both the biogeography and genomic contents of these
  Prochlorococcus lineages suggest adaptations to regions of the ocean wher
 e Fe limits the growth of most other phytoplankton.  In another study\, s
 everal genomes of the uncultivated SAR86 class of gamma-proteobacteria wer
 e attained.  Phylogenomic analyses establish SAR86 as a basal and diverge
 nt lineage of gamma-proteobacteria\, and the individual genomes display a 
 temperature-dependent distribution. The genomes contain an expanded capaci
 ty for the degradation of lipids and carbohydrates acquired using a wealth
  of tonB-dependent outer membrane receptors. Like the abundant planktonic 
 marine bacterial clade SAR11\, SAR86 exhibits metabolic streamlining\, but
  also a distinct carbon compound specialization\, possibly avoiding compet
 ition.   Both studies provided information potentially valuable to culti
 vation efforts\, and a substantial amount of unclassified metagenomic data
  was placed in ecological and evolutionary context. 4:00 pm
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