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About
Functional integration of gene products from the mitochondrial (mt) and nuclear genomes is essential to energy conversion and cell physiology. My research investigates the effects that mt gene loss has on cellular networks by utilizing new RNA sequencing technologies and a biological system that is undergoing rapid mt tRNA gene loss. I am testing multiple hypothesis related to the evolutionary mechanisms that facilitate the functional replacement of mt tRNA genes with anciently-divergent nuclear counterparts and how these changes “rewire” networks of interactions with numerous enzymes.
I'm passionate about understanding the evolutionary forces that shape genomes over time. I love to discuss all things molecular evolution, endosymbiosis, phylogenetics, horizontal gene transfer, art and music.
Publications
- Incompatibility and interchangeability in molecular evolution Genome Biology and Evolution, 1, 2023.
- Aminoacyl-tRNA synthetase evolution within the dynamic tripartite translation system of plant cells bioRxiv.
- Extensive retargeting of plant aminoacyl tRNA synthetases correlates with mitochondrial tRNA gene loss bioRxiv, 2022.
- Iterative deletion of gene trees detects extreme biases in distance-based phylogenomic coalescent analyses bioRxiv, 2022.
- Combining tRNA sequencing methods to characterize plant tRNA expression and post-transcriptional modification RNA Biology, 2021.
- Hopeful monsters: unintended sequencing of famously malformed mite mitochondrial tRNAs reveals widespread expression and processing of sense--antisense pairs NAR Genomics and Bioinformatics, 1, 2021.
- Iterative deletion of gene trees quantifies extreme biases in distance-based phylogenomic coalescent analyses Molecular Phylogenetics and Evolution.
- Rapid shifts in mitochondrial tRNA import in a plant lineage with extensive mitochondrial tRNA gene loss Molecular Biology and Evolution, 12, 2021.
- Interchangeable parts: The evolutionarily dynamic tRNA population in plant mitochondria Mitochondrion.
- CyMIRA: The Cytonuclear Molecular Interactions Reference for Arabidopsis Genome Biology and Evolution, 8, 2019.
- Partitioned coalescence support reveals biases in species-tree methods and detects gene trees that determine phylogenomic conflicts Molecular Phylogenetics and Evolution, 2019.
- Cytonuclear integration and co-evolution Nature Reviews Genetics, 2018.
- The mitonuclear dimension of Neanderthal and Denisovan ancestry in modern human genomes Genome Biology and Evolution, 6, 2017.
- Linear plasmids and the rate of sequence evolution in plant mitochondrial genomes Genome Biology and Evolution, 2, 2016.