Assistant ProfessorOffice: Biology Building 438Phone: 970-491-2256Website: https://sites.google.com/site/danielbsloan/Education: Ph.D. University of VirginiaEmail: firstname.lastname@example.org
I am looking for researchers interested in molecular evolution and genomics. If you would like to discuss joining the lab, please e-mail me and include a brief description of your research interests. Across the tree of life, biological organisms exhibit remarkable diversity in genome size, structure, and function. My research aims to elucidate the evolutionary forces that create and maintain this diversity. In many organisms, DNA is partitioned between two or more genomic compartments within the same cell. For example, eukaryotic cells contain both nuclear and organelle genomes, and many organisms harbor microbial endosymbionts inside their own cells. One of the overarching hypotheses that I am investigating is that interactions between these co-occurring genomes represent a major mechanism of genome evolution. This work has involved diverse organisms, including flowering plants, sap-feeding insects, endosymbiotic bacteria, and humans and generally requires a combination of approaches, including field sampling of natural populations, molecular genetic techniques, and computational genomic analysis. To learn more about research in the lab, please visit our lab website.
Sloan DB, Warren JM, Williams AW, Wu Z, Abdel-Ghany SE, Chicco AJ, Havird JC. 2018. Cytonuclear integration and co-evolution. Nature Reviews Genetics. 19: 635-648.
Sloan DB, Broz AK, Sharbrough J, Wu Z. 2018. Detecting rare mutations and DNA damage with sequencing-based methods. Trends in Biotechnology. 36: 729-740.
Sloan DB. 2017. Nuclear and mitochondrial RNA editing systems have opposite effects on protein diversity. Biology Letters. 13: 20170314.
Sloan DB, Havird JC, Sharbrough J. 2017. The on-again, off-again relationship between mitochondrial genomes and species boundaries. Molecular Ecology. 26: 2212-2236.
Rockenbach K, Havird JC, Monroe JG, Triant DA, Taylor DR, Sloan DB. 2016. Positive selection in rapidly evolving plastid-nuclear enzyme complexes. Genetics. 204: 1507-1522.
Havird JC, Sloan DB. 2016. The roles of mutation, selection, and expression in determining relative rates of evolution in mitochondrial vs. nuclear genomes. Molecular Biology and Evolution. 33: 3042-3053.
Moran NA, Sloan DB. 2015. The hologenome concept—helpful or hollow? PLoS Biology. 13: e1002311.
Havird JC, Whitehill NS, Snow CD, Sloan DB. 2015. Conservative and compensatory evolution in oxidative phosphorylation complexes of angiosperms with highly divergent rates of mitochondrial genome evolution. Evolution. 69: 3069-3081.
Sloan DB, Fields PD, Havird JC. 2015. Mitonuclear linkage disequilibrium in human populations. Proceedings of the Royal Society of London B: Biological Sciences. 282: 20151704.
Wu Z, Cuthbert JM, Taylor DR, Sloan DB. 2015. The massive mitochondrial genome of the angiosperm Silene noctiflora is evolving by gain or loss of entire chromosomes. Proceedings of the National Academy of Sciences USA. 112:10185-10191.
Sloan DB, Triant DA, Wu M, Taylor DR. 2014. Cytonuclear interactions and relaxed selection accelerate sequence evolution in organelle ribosomes. Molecular Biology and Evolution. 31: 673-682.
Sloan DB, Nakabachi A, Richards S, Qu J, Murali SC, Gibbs RA, Moran NA. 2014. Parallel histories of horizontal gene transfer facilitated extreme reduction of endosymbiont genomes in sap-feeding insects. Molecular Biology and Evolution. 31: 857-871.
Sloan DB, Alverson AJ, Chuckalovcak JP, Wu M, McCauley DE, Palmer JD, Taylor DR. 2012. Rapid evolution of enormous, multichromosomal genomes in flowering plant mitochondria with exceptionally high mutation rates. PLoS Biology. 10: e1001241.